2013-2022

Written By Brittan Goetz

  • CDDO-Imidazolide targets multiple amino acid residues on the Nrf2 adaptor, Keap1.   J. Med. Chem. 63: 9965-9976, 2020.

  • https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01088

  • Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.  Pharmacological Res 100: 135-147, 2015  https://www.sciencedirect.com/science/article/abs/pii/S1043661815001577

  • Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. J. Clin. Invest 124: 2472-2482, 2014.  https://pubmed.ncbi.nlm.nih.gov/24837432/

  • Complete protection against aflatoxin B1-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold. Cancer Prev Res 7:658-665, 2014.  https://pubmed.ncbi.nlm.nih.gov/24662598/

  • Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP-mouse model of Parkinson’s disease. Antioxid Redox Signal 18:139-57, 2013  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514006/

Brittan Goetz http://www.brittanbaylygoetz.com
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2011-2012